CAS NO: | 949021-68-5 |
包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
Cas No. | 949021-68-5 |
别名 | 芒柄花黄素-3'-磺酸钠,Sul-F |
Canonical SMILES | [O-]S(C1=C(OC)C=CC(C2=COC3=CC(O)=CC=C3C2=O)=C1)(=O)=O.[Na+] |
分子式 | C16H11NaO7S |
分子量 | 370.31 |
溶解度 | Water: 25 mg/mL (67.51 mM) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Sodium formononetin-3'-sulfonate (Sul-F) is a water-sol. derivate of formononetin. IC50 value:Target: Research results showed that treatment with Sul-F significantly prevented the elevation of ST-segment level, decreased the contents of creatine kinase-MB, lactate dehydrogenase, alanine aminotransferase and cardiac troponin T in serum and reduced the myocardium necrosis scores. These findings indicate that Sul-F has a protective potential against myocardial infarction injury. A possible mechanism for the protective effect is the elevated expression of endogenous antioxidant defense enzymes degraded lipid peroxidn. products and improved energy metab. of cardiac mitochondrial, thus attenuating cardiocyte apoptosis. Other reaearch results showed that sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities. [1]. Zhang, Shumin; Tang, Xuexi; Tian, Jingwei et al. Cardioprotective effect of sulphonated formononetin on acute myocardial infarction in rats. Basic & Clinical Pharmacology & Toxicology (2011), 108(6), 390-395. [2]. Wang, Qiuya; Meng, Qinghua; Zhang, Zunting et al. Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin. Yaoxue Xuebao (2009), 44(4), 386-389. [3]. Cardioprotective Effect of Sulfonated Formononetin on Acute Myocardial Infarction in Rats. |