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TBK1/IKKε-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
TBK1/IKKε-IN-1图片
CAS NO:2058264-32-5
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
TBK1/IKKε-IN-1 是一种双重 TBK1 和 IKKε 抑制剂，IC50s 值<100 nM。详细信息请参考专利文献 US20160376283 A1 中 Example 60 中的化合物 274。
Cas No.2058264-32-5
Canonical SMILESO=C(C1=CC(OC)=C(C2=CC3=NC=CC(C4=CC=C(OC5CCOCC5)C(C#N)=C4)=C3O2)N=C1)N(C)C
分子式C28H26N4O5
分子量498.53
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of<100 nM. TBK1|100 nM (IC50)|IKKε|100 nM (IC50)

IKKε and TBK1 are serine/threonine kinases which are highly homologous to one another and other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognised by the Toll-like receptors 3 and 4 and the RNA helicases RIG-I and MDA-5 and result in activation of the TRIF-TBK1/IKKε-IRF3 signalling cascade, which results in a type I interferon response[1].

[1]. Brian A. Sherer, et al. Tbk/ikk inhibitor compounds and uses thereof. US 20160376283 A1.