ODN 20844

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ODN 20844

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1964506-29-3

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议

产品介绍

ODN 20844，鸟嘌呤修饰的抑制性寡核苷酸 (INH-ODN)，是一种TLR7和TLR9(Toll-like receptor) 的抑制剂，其亲本为 INH-ODN 2088。ODN 20844 可以破坏 TLR7 和 TLR9 介导的免疫细胞免疫反应。ODN 20844 序列：5'-TCCTGGCGc7GGGAAGT-3'。

生物活性

ODN 20844, a guanine-modified inhibitory oligonucleotide (INH-ODN), is aTLR7andTLR9(Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 20844 disrupts TLR7- and TLR9-mediated immune cell immune responses. ODN 20844 sequence: 5'-TCCTGGCGc7GGGAAGT-3'^[1].

IC₅₀& Target^[1]

TLR7

TLR9

体外研究
(In Vitro)

ODN 20844 (0.01-10 μM, 24 h) can effectively block TLR9-mediated IFN-α release and inhibit IL-6 secretion in human peripheral blood mononuclear cells^[1].
ODN 20844 (0.01-10 μM, 24 h) has better inhibitory effect on imiquimod-induced IL-6 secretion in human B cells than INH-ODN 2088^[1].

性状

Solid

CAS 号

1964506-29-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)