Ningetinib is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) withIC₅₀s of 6.7, 1.9 and<1.0 nM forc-Met,VEGFR2andAxl, respectively.

Ningetinib is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC₅₀s of 6.7, 1.9 and<1.0 nM for c-Met, VEGFR2 and Axl, respectively. In cell-based functional assays, Ningetinib (CT053PTSA) inhibits HGF and VEGF-stimulated HUVEC proliferation and microvascular angiogenesis in rat aortic rings with IC₅₀values of 8.6 and 6.3 nM, respectively^[1].

When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib (CT053PTSA) potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues. In orthotopic U87MG human glioblastoma xenograft model, Ningetinib prolongs the median survival time (MST) and yields significant increase in life-span value (ILS=32%, p=0.003) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group^[1].

556.58

Solid

C₃₁H₂₉FN₄O₅

1394820-69-9

宁格替尼

Room temperature in continental US; may vary elsewhere.

DMSO : 16.67 mg/mL(29.95 mM;Need ultrasonic)

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