UNC2250

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UNC2250

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1493694-70-4

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

UNC2250 是一种有效选择性的Mer抑制剂，IC₅₀为 1.7 nM，比相关的激酶 Axl 和 Tyro3 选择性高 160 倍和 60 倍。

生物活性

UNC2250 is a potent and selectiveMerinhibitor with anIC₅₀of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.

IC₅₀& Target

IC50: 1.7 nM (Mer)^[1]

体外研究
(In Vitro)

UNC2250 (5-500 nM; 1 hour) inhibits Mer phosphorylation in 697 B-ALL cells with an IC₅₀value of 9.8 nM^[1].
UNC2250 efficiently inhibits ligand-dependent phosphorylation of a chimeric protein consisting of the extracellular and transmembrane domains of the epidermal growth factor (EGF) receptor and the intracellular tyrosine kinase domain of Mer^[1].
UNC2250 incubation inhibits colony formation in soft agar cultures of the BT-12 rhabdoid tumor and the Colo699 NSCLC cell lines^[1].

Western Blot Analysis^[1]

Cell Line:	697 B-ALL cells
Concentration:	5, 10, 20, 50, 100, 250, 500 nM
Incubation Time:	1 hour
Result:	Inhibits Mer phosphorylation in 697 B-ALL cells with an IC₅₀value of 9.8 nM.

分子量

440.58

性状

Solid

Formula

C₂₄H₃₆N₆O₂

CAS 号

1493694-70-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 20 mg/mL(45.39 mM;ultrasonic and warming and heat to 60℃)

0.1 M HCL : 12.5 mg/mL(28.37 mM;ultrasonic and adjust pH to 3 with HCl)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.2697 mL	11.3487 mL	22.6974 mL
5 mM	0.4539 mL	2.2697 mL	4.5395 mL
10 mM	0.2270 mL	1.1349 mL	2.2697 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。