Dubermatinib (TP-0903) is a potent and selectiveAxlreceptor tyrosine kinase inhibitor with anIC₅₀value of 27 nM.

IC50: 27nM (Axl)^[1]

Dubermatinib (TP-0903) displays a potent activity against AXL with an IC₅₀of 0.027 μM. Dubermatinib (TP-0903) shows extremely potent activity in cell viability assays with an IC₅₀of 6 nM against the pancreatic cancer cell line PSN-1. Dubermatinib (TP-0903) is evaluated for its ability to block GAS6-mediated activation of AXL in pancreatic cancer cells. PSN-1 cells are serum-starved and then stimulated with GAS6 in the presence of various concentrations of TP-0903^[1].

516.06

Solid

C₂₄H₃₀ClN₇O₂S

1341200-45-0

Room temperature in continental US; may vary elsewhere.

DMSO : 3.33 mg/mL(6.45 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： 0.5%CMC-Na/saline water

  Solubility: 10 mg/mL (19.38 mM); Suspended solution; Need ultrasonic