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(±)-4-hydroxy Propranolol(hydrochloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(±)-4-hydroxy Propranolol(hydrochloride)图片
CAS NO:14133-90-5
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
4-Hydroxypropranolol hydrochlorid 是 Propranolol 的活性代谢物。
Cas No.14133-90-5
别名4-羟基普萘洛尔盐酸盐,(±)-4-hydroxy Propranolol hydrochloride
化学名4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-1-naphthalenol, monohydrochloride
Canonical SMILESOC1=CC=C(OCC(O)CNC(C)C)C2=C1C=CC=C2.Cl
分子式C16H21NO3o HCl
分子量311.8
溶解度≤30mg/ml in ethanol;50mg/ml in DMSO;30mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 1.1 μM: inhibits lipid peroxidation in endothelial cells.

(±)-4-hydroxy Propranolol, an active metabolite of propranolol, blocks β1- and β2-adrenergic receptors (β1-ARs, β2-ARs). Also, (±)-4-hydroxy propranolol has antioxidant properties at micromolar concentrations. β1- and β2-ARs, expressed in cardiac myocytes, mediate an increase in contractility by Gs-dependent coupling to adenylyl cyclase.

In vitro: Compared to the control, (±)-4-hydroxy propranolol potently blocked the lipid peroxidation in a concentration-dependent fashion in endothelial cells. When pretreated with (±)-4-hydroxy propranolol at 0.067 to 6.7 μM, the degrees of protection were increased against the glutathione loss in the endothelial cells. Additionally, (±)-4-hydroxy propranolol effectively preserved the loss of cell survival because of the radical stress [1].

In vivo: Rats were injected intravenously with (±)-4-hydroxy propranolol into the femoral vein at 0.1 ml/100 g. (±)-4-hydroxy Propranolol induced an increase in heart rate in a dose-dependent manner in rats depleted of catecholamines, which suggested that (±)-4-hydroxy propranolol had intrinsic sympathomimetic activity. The response of (±)-4-hydroxy propranolol was inhibited when rats were pretreated with 0.5 mg/kg propranolol [2].

References:
[1].  Mak, I. Potent Antioxidant Properties of 4-Hydroxyl-propranolol. Journal of Pharmacology and Experimental Therapeutics. 2003; 308(1): 85-90.
[2].  FITZGERALD, J., & O'DONNELL, S. Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. British Journal of Pharmacology. 1971; 43(1): 222-235.