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Pyrrolidino PAF C-16
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Pyrrolidino PAF C-16图片
CAS NO:91021-63-5
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Cas No.91021-63-5
化学名1-O-hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphoryl-N-methyl-pyrrolidinium ethanol
Canonical SMILESCCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP(OCC[N+]1(C)CCCC1)([O-])=O
分子式C28H56NO7P
分子量549.7
溶解度≤25mg/ml in PBS
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pyrrolidino PAF C-16 is a synthetic analog of PAF C-16 with hypotensive action [1][2].

Platelet activating factor (PAF; C16), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages. PAF have potent hypotensive activity. C16-PAF was about three times more potent than C18-PAF in the activity of releasing serotonin [1][2].

Pyrrolidino PAF C-16, a synthetic analog of PAF C-16, is a potent mediator of PAF-like activities, including hypotension and platelet aggregation [1][2].

In male Wistar rats, Pyrrolidino PAF C-16 dose-dependently decreased blood pressure and the duration of the hypotension was also dose-dependent. Pyrrolidino PAF C-16 was 3-10 times more potent than natural PAF in the hypotensive activity [1][2].

References:
[1].  Shigenobu K, Masuda Y, Tanaka Y, et al. Platelet activating factor analogues: lack of correlation between their activities to produce hypotension and endothelium-mediated vasodilation. J Pharmacobiodyn. 1985 Feb;8(2):128-33.
[2].  Kasuya Y, Masuda Y, Shigenobu K. Hypotensive actions of some analogues of platelet-activating factor (PAF) with higher potencies than natural PAF. Can J Physiol Pharmacol. 1984 Apr;62(4):457-9.