SPI-112 is a potent, selective and competitiveSHP2(PTPN11)inhibitor withIC₅₀s of 1 μM, 18.3 μM and 14.5 μM forSHP2, protein tyrosinephosphatase(PTP) and PTP1B, respectively^[1][2].

IC50: 1 μM (SHP2), 18.3 μM (PTP) and 14.5 μM (PTP1B)^[2]

SPI-112 has a polar -NO₂or a negatively charged -COOH group and has no detectable cellular activity, suggesting that SPI-112 is not cell permeable^[1].
In surface plasmon resonance (SPR) binding assay, SPI-112 displays a 1:1 stoichiometric binding kinetics to SHP2 with a kinetic constant K_Dof 1.30 μM. Enzyme kinetic data obtained with SPI-112 are best fitted with the competitive inhibition model (K_iof 0.8 μM), suggesting that SPI-112 interacts with the catalytic site of SHP2^[1].

468.46

Solid

C₂₂H₁₇FN₄O₅S

1051387-90-6

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

DMSO : 50 mg/mL(106.73 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。