CD31 (PECAM-1) TFA is platelet endothelial cell adhesion molecule-1, serves as theendothelial cell-specificreceptor of clostridium perfringens b-Toxin (CPB). CD31 TFA is also anER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 TFA peptide is able to sustain phosphorylation of theCD31 ITIM₆₈₆and ofSHP2and to inhibitTCR-induced T-cell activation^[1]-[5].

CD31 TFA is a trans-homophilic co-signaling protein at the crossroad between mechanical stress, metabolism and inflammation^[1].
CD31 TFA is a ER-MP12 antigen, exerts function as promoting cell adhesion between endothelial cells, enabling transmigration of leukocytes across vascular endothelium, and producing signaling to up-regulation of other adhesion molecules in neighboring cells^[2].
Clostridium perfringens b-toxin (CPB) is a highly active b-pore-forming toxin (b-PFT) and the essential virulence factor for fatal, necro-hemorrhagic enteritis^[3].
CD31 TFA serves as the specific membrane receptor for clostridium perfringens b-toxin (CPB) on endothelial cells. CD31 TFA directly interacts with CPB, with the membrane proximal Ig6 domain^[3].
CD31 TFA also serves as a therapeutic target in atherosclerosis^[4].
CD31 TFA (0, 25, 50, 100 μg/mL) induces proliferative response to TCR engagement of human PBMCs in a dose-dependent manner^[5].

2715.12

C₁₂₁H₂₀₃F₃N₃₆O₃₁

NHASSVPRSKILTVRVILAPWKK

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