CAS NO: | 148741-30-4 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibitsTrKAphosphorylation (IC50of 10 μM), but notTrKBandTrKC. Tyrphostin AG 879 is also a selectiveErbB2tyrosine kinase inhibitor with anIC50of 1 μM, and has at least 500-fold higher selectivity toErbB2thanEGFR. Tyrphostin AG 879 has anticancer activity[1][2][3]. | ||||||||||||||||
IC50& Target | IC50: 10 μM (TrKA phosphorylation)[1] | ||||||||||||||||
体外研究 (In Vitro) | Tyrphostin AG 879 (0.5-50 μM; 48 hours; HL-60, U-937, PC-3, HTB-82, HTB-114, TE-671, HTB-115 and HTB-88 cells) treatment significantly and dose dependently decreases cell proliferation in all the cell lines[1]. Cell Proliferation Assay[1]
Apoptosis Analysis[1]
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体内研究 (In Vivo) | Tyrphostin AG 879 (100 mg/kg;subcutaneous injection; administered 10 times in 19 days; for 21 days; athymic, immunodepressed NOD/SCID female mice) treatment induces in vivo a decrease in cancer growth in grafted athymic NOD/SCID mice[1].
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分子量 | 316.46 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H24N2OS | ||||||||||||||||
CAS 号 | 148741-30-4 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 50 mg/mL(158.00 mM;Need ultrasonic) 配制储备液
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