| CAS NO: | 108294-57-1 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 108294-57-1 |
| 化学名 | N-(2,6-dichloro-4-iodophenyl)-4,5-dihydro-1H-imidazol-2-amine, monohydrochloride |
| Canonical SMILES | ClC1=CC(I)=CC(Cl)=C1NC2=NCCN2.Cl |
| 分子式 | C9H8Cl2IN3o HCl |
| 分子量 | 392.5 |
| 溶解度 | ≤1mg/ml in ethanol;1mg/ml in DMSO;0.25mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | p-iodo-Clonidine (hydrochloride) is a partial agonist of the alpha 2-adrenergic receptor [1]. The adrenergic receptors are G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. There are two main groups of adrenergic receptors: α receptors and β receptors. α2-adrenergic receptor is a Gi coupled receptor, which causes a decrease in neurotransmitter release, as well as a decrease of cAMP activity resulting in smooth muscle contraction [1]. p-iodo-Clonidine (hydrochloride) is a partial agonist of the alpha 2-adrenergic receptor. Clonidine is an antihypertensive α2-adrenergic receptor agonist. PIC had minimal agonist activity in inhibiting adenylate cyclase in platelet membranes through α2-adrenergic receptor, but it increased platelet aggregation induced by ADP with EC50 value of 1.5 μM. PIC also inhibited epinephrine-induced aggregation with IC50 value of 5.1 μM. PIC competed for [3H]bromoxidine binding with Ki value of 1.0 nM. PIC bound to the alpha 2B-AR in NG-10815 cell membranes with Kd value of 0.5 +/- 0.1 nM [1]. Reference: |
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