Animal experiment:

For the depletion studies, 240 1-day-old Cobb chicks are used. The chickens are housed in pens that contains 30 birds each (10 birds/m2) and are provided ad libitum access to water and non-medicated feed. The chickens are randomly allocated into four experimental groups, labeled from A to D, containing 80 birds each. Chickens in group A form the untreated control group, whereas those in group C are treated with 10 mg/kg bw of Sulfaquinoxaline sodium salt, which is administered via drinking water from the 32nd to 34th day of breeding[1].

Sulfaquinoxaline sodium salt is an antibiotic which has activity against a broad spectrum of Gram-negative and Gram-positive bacteria.

The antimicrobial Sulfaquinoxaline sodium salt has activity against a broad spectrum of Gram-negative and Gram-positive bacteria and is widely used in poultry production as therapeutic or prophylactic agent. Concentrations of Sulfaquinoxaline sodium salt that are higher than the drug's maximum residue limit (MRL) (100 μg/kg) are found in the breast muscle until the 36th day of breeding in this study[1].

[1]. de Assis DC, et al. Evaluation of the Presence and Levels of Enrofloxacin, Ciprofloxacin, Sulfaquinoxaline and Oxytetracycline in Broiler Chickens after Drug Administration. PLoS One. 2016 Nov 15;11(11):e0166402.