Escitalopram Oxalate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

219861-08-2

包装与价格：

包装	价格(元)
10 mM * 1 mL in Water	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

依他普仑草酸盐
(S)-Citalopram oxalate
(S)-(+)-Citalopram oxalate

产品介绍

Escitalopram ((S)-Citalopram) oxalate 是外消旋 Citalopram 的 S-对映体，是一种选择性 5-羟色胺再摄取抑制剂(SSRI)，K_i为 0.89 nM，比 R(-)-enantiomer 结合亲和力高 30 倍。Escitalopram oxalate 对多巴胺转运体 (DAT) 和去甲肾上腺素转运体 (NET) 均有选择性。Escitalopram oxalate 是研究抑郁症的抗抑郁药。

生物活性

Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selectiveserotonin reuptakeinhibitor (SSRI) with aK_iof 0.89 nM. Escitalopram oxalate has ~30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over bothdopamine transporter(DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression^[1]^[2].

IC₅₀& Target

Ki: 0.89 nM (serotonin transporter), 10500 nM (DAT), 8150 nM (NET)^[1]

体内研究
(In Vivo)

Escitalopram (10 mg/kg; i.p.; daily for 28 days) ameliorates cognitive impairments and selectively attenuates phosphorylated tau accumulation in stressed rats^[3].
Chronic administration of Escitalopram (daily; drinking water for a total of 4 months) significantly reduces plaque load by 28% and 34% at 2.5 and 5 mg/d, respectively^[4].

Animal Model:	Male Sprague-Dawley rats^[3]
Dosage:	10 mg/kg
Administration:	I.p.; daily for 28 days
Result:	Could selectively decrease phosphorylated tau accumulation in the hippocampus of stressed rats and could distinctly alleviate the hyperactivity of the HPA axis in both depressive and resistant rats.

Animal Model:	APP-PS1 hemizygous female mice (4 months of age)^[4]
Dosage:	2.5-5 mg/kg
Administration:	Daily; drinking water for a total of 4 months
Result:	At both doses significantly reduced plaque burden within the brains of these mice compared to littermate controls that drank only water. Hippocampal plaque load was significantly reduced by 28.7% and 34.4 % for ESC 2.5 mg/day and 5 mg/day, respectively.

Clinical Trial

分子量

414.43

性状

Solid

Formula

C₂₂H₂₃FN₂O₅

CAS 号

219861-08-2

中文名称

依他普仑草酸盐；草酸右旋西酞普兰

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : ≥ 14.29 mg/mL(34.48 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.4130 mL	12.0648 mL	24.1295 mL
5 mM	0.4826 mL	2.4130 mL	4.8259 mL
10 mM	0.2413 mL	1.2065 mL	2.4130 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: ≥ 100 mg/mL (241.30 mM); Clear solution

*以上所有助溶剂都可在本网站选购。