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Brivudine(Bromovinyldeoxyuridine)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Brivudine(Bromovinyldeoxyuridine)图片
CAS NO:69304-47-8
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
25mg电议
50mg电议
100mg电议
200mg电议

产品介绍
Brivudine (Bromovinyldeoxyuridine) 是一种具有抗病毒活性的胸苷类似物,适用于急性带状疱疹的早期治疗。
Cas No.69304-47-8
别名溴夫定; Bromovinyldeoxyuridine; BVDU
Canonical SMILESOC[C@@H]1[C@H](C[C@H](N2C(NC(C(/C=C/Br)=C2)=O)=O)O1)O
分子式C11H13BrN2O5
分子量333.14
溶解度DMSO : ≥ 330 mg/mL (990.57 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.

Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir[1]. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage[2].

At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia[1].

[1]. Rabasseda X, et al. Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Drugs Today (Barc). 2003 May;39(5):359-71. [2]. Keam SJ, et al. Brivudin (bromovinyl deoxyuridine). Drugs. 2004;64(18):2091-7; discussion 2098-9.