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NM107(2'-C-Methylcytidine)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NM107(2'-C-Methylcytidine)图片
CAS NO:20724-73-6
包装与价格:
包装价格(元)
5mg电议
10mM (in 1mL Water)电议
50mg电议
100mg电议

产品介绍
NM107 (2'-C-Methylcytidine) (2'-C-Methylcytidine) 是丙型肝炎病毒 (HCV) NS5B 聚合酶的核苷抑制剂,NM107 (2'-C-Methylcytidine) 在野生型复制子中的 EC50细胞为 1.85 μM.
Cas No.20724-73-6
别名2'-C-甲基胞嘧啶核苷,2'-C-Methylcytidine; NM-107
Canonical SMILESNC(C=CN1[C@@H]2O[C@H](CO)[C@@H](O)[C@@]2(C)O)=NC1=O
分子式C10H15N3O5
分子量257.24
溶解度Water : ≥ 50 mg/mL (194.37 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NM107 is a inhibitors of HCV RNA replication with IC50 of 7.0 μM in vitro.IC50 value: 7.0 μMTarget:HCV RNA replicationNM107 is a potent and selective inhibitor of flavi- and pesti-virus replication in cell culture, with inhibitory activity and cytotoxicity against HCV 1b replicon cells, IC50 is 1.13 μM. Intracellular HCV RNA in HCV-infected cells treated the HCV polymerase inhibitor NM107 shows a similar pattern of decline. NM107 are currently being investigated as additional therapeutic agents for HCV infection. NM107 inhibits bovine viral diarrhea virus (BVDV) replication (EC50 0.67 nM), eliminates persistent BVDV infection at nontoxic concentrations.

[1]. McCown MF, et al. The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleosidepolymerase or protease inhibitors. Antimicrob Agents Chemother. 2008 May;52(5):1604-1612.