Harmane-d2 is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity forI1-Imidazoline receptor(IC₅₀=30 nM) overα2-adrenoceptor(IC₅₀=18 μM). Harmane is also a potent and selective inhibitor ofmonoamine oxidase(MAO)(IC₅₀s=0.5 and 5 μM forhuman MAO A/B, respectively)^[1][2][3][4].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

184.23

C₁₂H₈D₂N₂

哈尔满碱 d2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.