Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selectiveI1imidazoline receptoragonist. Rilmenidine phosphate is analpha 2-adrenoceptoragonist. Rilmenidine phosphate inducesautophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na⁺/H⁺antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic proteinBaxthus inducing the perturbation of the mitochondrial pathway andapoptosisin human leukemic K562 cells^[1][2][3].

Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors^[1].
Rilmenidine phosphate (25-100 μM; 24 hours) inhibits K562 cell proliferation^[2].

Rilmenidine phosphate-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age^[3].
Rilmenidine phosphate decreases levels of mutant huntingtin^[3].

278.24

Solid

C₁₀H₁₉N₂O₅P

85409-38-7

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : 62.5 mg/mL(224.63 mM;Need ultrasonic)

DMSO : 5 mg/mL(17.97 mM;ultrasonic and warming and heat to 80℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。