Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive directthrombininhibitor (K_i=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC₅₀=10 nM)^[1][2].

Ki: 4.5 nM (thrombin)^[1]

Dabigatran (BIBR 953) shows concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human platelet-poor plasma at concentrations of 0.23, 0.83 and 0.18 μM, respectively^[1].

Dabigatran (0.01-0.1 mg/kg; i.v.) inhibits clot formation with an ED₅₀of 0.033 mg/kg in Wessler model^[3].

471.51

Solid

C₂₅H₂₅N₇O₃

211914-51-1

达比加群

Room temperature in continental US; may vary elsewhere.

0.1 M HCL : 12.5 mg/mL(26.51 mM;Need ultrasonic)

H₂O :< 0.1 mg/mL(insoluble)

DMSO :< 1 mg/mL(insoluble or slightly soluble)

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