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Sterculic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sterculic Acid图片
CAS NO:738-87-4
包装:25mg
市场价:9000元

产品名称
苹婆酸
产品介绍
Sterculic acid 是一种硬脂酰辅酶 A 去饱和酶 1 (SCD1) 抑制剂。Sterculic acid 特异性抑制 delta-9 去饱和酶 (Δ9D) 活性,IC50值为 0.9 μM。
生物活性

Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with anIC50value of 0.9 μM[1].

IC50& Target[1]

delta-9 desaturase

0.9 μM (IC50)

体外研究
(In Vitro)

Sterculic acid (SA) is a cyclopropene fatty acid originally found in the seeds of the plantSterculia foetidawith numerous biological activities[2].
Sterculic acid is able to reduce adrenomedullin expression (AP, RP, APS, IML, in preparation)[2].
Sterculic acid is also able to mediate anti-inflammatory and protective effects[2].
Sterculic acid has a potent luteolytic effect in ovines by inhibition in the synthesis of progesterone, which causes luteal regression[2].

体内研究
(In Vivo)

Sterculic acid has been proposed as a potential tool for the treatment of metabolic syndrome (MS) since it inhibits the activity of the stearoyl-CoA desaturase-1 (SCD1) in vivo[3].

分子量

294.47

性状

Liquid

Formula

C19H34O2

CAS 号

738-87-4

中文名称

苹婆酸

结构分类
  • Ketones, Aldehydes, Acids
来源
  • Plants
  • Sterculiaceae
  • Sterculia foetidaLinn.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form-20°C3 years
In solvent-80°C6 months
-20°C1 month