CAS NO: | 1018675-35-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | CVT-12012 is a potent and orally bioavailablestearoyl-coA desaturase(SCD)inhibitor, withIC50sof 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively. | ||||||||||||||||
IC50& Target | IC50: 38 nM (rat microsomal), 6.1 nM (human HEPG2)[1][2]. | ||||||||||||||||
体外研究 (In Vitro) | CVT-12012 (Compound 5b) displays the highest potency in both the microsomal and the HEPG2 SCD assays (IC5038 nM and 6.1 nM, respectively) compared to the other methyl-substituted compounds[1]. | ||||||||||||||||
体内研究 (In Vivo) | In a rat PK study, CVT-12012 demonstrates good oral bioavailability (78%). It appears that the oral absorption of CVT-12012 is not affected by a significant Pgp efflux, which is expected based on Caco-2 assay result. The plasma clearance of CVT-12012 is high (88 mL/min/kg) with elimination half-life of approximately 1 h[1]. | ||||||||||||||||
分子量 | 434.41 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H21F3N4O3 | ||||||||||||||||
CAS 号 | 1018675-35-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 125 mg/mL(287.75 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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