PF-4950834 is a potent, selective, orally bioavailable, ATP-competitiverho kinaseinhibitor withIC₅₀values of 8.35 nM and 33.12 nM againstROCK2andROCK1, respectively. PF-4950834 inhibits neutrophil migration^[1].

PF-4950834 shows inhibition against the AGC (cAMP-dependent protein kinase/protein kinase G/protein kinase C) kinase family with IC₅₀values of 8.35, 33.12, 102, 216, 321, 384, 411, 424, 457, 578, 736, 756 and 2900 nM for ROCK2, ROCK1, PRKG1, PKN1, SGK2, PRKG2, MSK1, PKA, PRKX, MSK2, P70S6K, PKC_ηand SGK1, respectively^[1].

345.39

C₂₁H₁₉N₃O₂

1256264-62-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.