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Bopindolol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bopindolol图片
CAS NO:62658-63-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
波吲洛尔
(±)-Bopindolol
产品介绍
Bopindolol ((±)-Bopindolol) 是一种口服活性的 β-肾上腺素受体 (ARs) 拮抗剂,具有部分激动剂活性。Bopindolol 对 β1-和 β2-ARs 无选择性,对 β3-AR 亚型亲和力低。Bopindolol 具有内在拟交感神经和膜稳定作用,抑制肾素 (renin) 分泌,并与5-HT 受体相互作用。Bopindolol 是 Pindolol (HY-B0982) 的前体药物,可用于原发性和肾血管性高血压的研究。
生物活性

Bopindolol ((±)-Bopindolol) is an orally active antagonist ofβ-adrenoceptors (ARs)with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibitsreninsecretion, and interacts with5-HT receptors. Bopindolol is a prodrug ofPindolol(HY-B0982). Bopindolol can be used for essential and renovascular hypertension research[1][2][3][4].

IC50& Target[1]

β2 adrenoceptor

 

Beta-1 adrenergic receptor

 

Beta-3 adrenergic receptor

 

体内研究
(In Vivo)

Bopindolol (intravenous injection; 8, 16 and 32 μg/kg) causes a dose-dependent inhibition of isoprenaline-induced tachycardia, and this agent is 4 times more potent than propranolol in anaesthetised dogs[1].
Bopindolol (0.3, 1 and 3 mg/kg; IP; single dosage) produces dose dependent decreases in diastolic blood pressure and in heart rate[2].

Animal Model:Male Wistar rats (260-300 g)[2]
Dosage:0.3, 1 and 3 mg/kg
Administration:IP; single dosage
Result:Produced dose dependent decreases in diastolic blood pressure, and the decrease of about 8 mmHg at 3 mg/kg.
Decreased the heart rate in a dose-dependent manner.
分子量

380.48

Formula

C23H28N2O3

CAS 号

62658-63-3

中文名称

波吲洛尔;吲苯脂心安

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.