CAS NO: | 215030-90-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | BMS493 is an inverse pan-retinoic acid receptor (RAR)agonist. BMS493 increases nuclear corepressor interaction withRARs. BMS493 also could prevent retinoic acid-induced differentiation[1][2]. | ||||||||||||||||
体外研究 (In Vitro) | BMS493 (100 nM; 6 days; ALDHhi UCB cells) treatment shows a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls. Newly expanded ALDHhi cells shows increased numbers of CD34 and CD133-positive cells, as well as a reduction in CD38 expression, a marker of hematopoietic cell differentiation[1]. Cell Viability Assay[1]
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体内研究 (In Vivo) | Intrapancreatic transplantation of cell progeny after expansion of ALDHhi cells with or without BMS493 shows no reduction of hyperglycemia in Streptozotocin-treated NOD/SCID mice. Thus, Umbilical cord blood (UCB)-derived ALDHhi cells effectively lost islet regenerative capacity during ex vivo expansion[1]. | ||||||||||||||||
分子量 | 404.50 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C29H24O2 | ||||||||||||||||
CAS 号 | 215030-90-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 50 mg/mL(123.61 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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