PKM2 activator 3 is a potentPKM2activator with anAC₅₀value of 90 nM. PKM2 activator 3 has good Caco-2 permeability, a low efflux ratio and high microsomal stability. PKM2 activator 3 can be used for researching anticancer^[1].
^{(AC₅₀: the concentration which gives 50% activation of enzyme.)}

PKM2^[1]

PKM2 activator 3 (compound 66) has good Caco-2 permeability, a low efflux ratio (0.84) and high microsomal stability (t1/2= 277.2 min in human liver microsomes and 117.5 min in mouse liver microsomes)^[1].

372.77

C₁₅H₁₁ClF₂N₂O₃S

1346113-84-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.