Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor withIC₅₀of 295 nm. Antithrombotic efficacy^[1].

PAI-749 is a potent and selective synthetic antagonist of plasminogen activator inhibitor 1 (PAI-1) that preserved tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) activities in the presence of PAI-1 (IC₅₀values, 157 and 87 nM, respectively)^[2].
PAI-749 quenches the fluorescence (Fl) of fluorophore-tagged PAI-1 (PAI-NBD119) with the apparent K_dof 254 nM) and the IC₅₀of 140 nM^[2].

501.62

Solid

C₃₂H₃₁N₅O

481631-45-2

Room temperature in continental US; may vary elsewhere.

DMSO : 125 mg/mL(249.19 mM;Need ultrasonic)

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