Sacubitril-d4 (AHU-377-d4) is the deuterium labeled Sacubitril. Sacubitril (AHU-377) is a potentNEPinhibitor with anIC₅₀of 5 nM. Sacubitril (AHU-377) is a component of the heart failure medicine LCZ696.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

415.52

C₂₄H₂₅D₄NO₅

1884269-07-1

沙库必曲 d4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.