(Rac)-Nebivolol

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(Rac)-Nebivolol

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

99200-09-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

(Rac)-R 065824

产品介绍

(Rac)-Nebivolol ((Rac)-R 065824) 是 Nebivolol 的外消旋异构体。Nebivolol 是一种具有选择性的β1 肾上腺素能受体拮抗剂，IC₅₀为 0.8 nM。在乙醇引起心脏毒性的早期阶段，Nebivolol 能预防 Nox2/NADPH 氧化酶上调和脂质过氧化。具有血管舒张活性。

生物活性	(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selectiveβ1-adrenergic receptorantagonist with anIC₅₀value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity^[1]^[2].
IC₅₀& Target	IC₅₀: 0.8 nM (β1-adrenergic receptor)^[1]
体内研究 (In Vivo)	Nebivolol (10 mg/kg; daily for 7 days) markedly improves endothelial dysfunction and increases P-VASP levels; prevents NOS III uncoupling; significantly inhibit NADPH oxidase in Angiotensin II-treated rats^[3].
分子量	405.44
Formula	C₂₂H₂₅F₂NO₄
CAS 号	99200-09-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.