CP-346086 is a potent and orally activemicrosomal triglyceride transfer protein (MTP)inhibitor, with anIC₅₀of 2.0 nM for human and rodent MTP. CP-346086 can lower plasmacholesteroland triglycerides in vivo^[1].

IC50: 2.0 nM (MTP)^[1]

CP-346086 (0.1-1000 nM) dose-dependently inhibits human MTP-mediated triglyceride transfer between vesicles with an IC₅₀of 2.0 nM^[1].
CP-346086 (24 h) inhibits apolipoprotein B (apoB) and triglyceride secretion (IC₅₀=2.6 nM) from Hep-G2 cells without affecting apoA-I secretion or lipid synthesis^[1].

CP-346086 (1-100 mg/kg; oral gavage once daily for 2 weeks) reduces plasma total, VLDL, and LDL cholesterol and triglycerides in mice^[1].
CP-346086 (25 mg/kg; a single p.o.) results in an almost complete inhibition of Tyloxapol-induced triglyceride accumulation in fasted rats^[1].
CP-346086 (0.1-10 mg/kg; a single p.o.) reduces acute plasma triglyceride in mice^[1].

477.48

C₂₆H₂₂F₃N₅O

186390-48-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.