JZP-MA-11

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JZP-MA-11

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1672691-50-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

JZP-MA-11 是一种正电子发射断层扫描 (PET) 配体，靶向内源性大麻素 α/β-水解酶结构域 6 (ABHD6) 酶。JZP-MA-11 选择性抑制 ABHD6，IC₅₀值为 126 nM。JZP-MA-11 可以透过血脑屏障 (BBB)。[18F]JZP-MA-11 具有用于靶向小鼠和非人灵长类动物 (NHP) 中大脑 ABHD6 的临床前评估的潜力。

生物活性

JZP-MA-11 is a positron emission tomography (PET) ligand targeting theendocannabinoid α/β-hydrolase domain 6 (ABHD6)enzyme. JZP-MA-11 selectively inhibits ABHD6 with anIC₅₀value of 126 nM. JZP-MA-11 can cross the blood-brain barrier (BBB). [18F]JZP-MA-11 has the potential for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP)^[1].

体外研究
(In Vitro)

JZP-MA-11 (10 μM) 对表达 CB₁或 CB₂的 HEK293 细胞中毛喉素 (HY-15371) 刺激的 cAMP 没有影响^[1]。

体内研究
(In Vivo)

JZP-MA-11 (1.5 mg/kg; 静脉给药; 示踪剂注射前 20 分钟) 导致大脑、肝脏、心脏和肾脏等富含 ABHD6 的器官的放射性摄取减少^[1]。

Animal Model:	C57BL6 mice (female, 10-12-week-old)^[1]
Dosage:	1.5 mg/kg
Administration:	IV; 20 min before tracer injection
Result:	Resulted in a decrease in radioactivity uptake in ABHD6-rich organs such as, brain, liver, heart, and kidneys.

分子量

336.38

Formula

C₁₅H₁₇FN₄O₂S

CAS 号

1672691-50-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.