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Protease-Activated Receptor-2,amide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Protease-Activated Receptor-2,amide图片
CAS NO:190383-13-2
包装:10mg, 25mg
包装与价格:
包装价格(元)
10mg电议
25mg电议

产品名称
SLIGKV-NH2
产品介绍

生物活性

Protease-Activated Receptor-2, amide (SLIGKV-NH2) is a highly potent agonist of PAR2 with IC50 of 10.4 uM. Protease-Activated Receptor-2, amide is one of a four family subgroup of G-protein-coupled receptors (GPCRs), called PARs. Protease-activated receptors are distinguished from other GPCRs through their unique proteolytic mechanism of activation. For PAR2, activating proteases, such as trypsin, tryptase and coagulation factors VIIa and Xa, cleave a specific extracellular amino-terminal domain of the receptor to reveal a "tethered ligand", SLIGKV- and SLIGRL- for human and mouse/rat PAR2, respectively, which subsequently interacts with the activation domain of the receptor, initiating intracellular signaling pathways.


化学数据

分子量614.78
分子式C28H54N8O7
CAS号190383-13-2
纯度>99%
溶解性(25°C)Water 30 mg/mL
储存和运输条件-20°C, sealed
常温运输及临时存放

不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

小鼠大鼠豚鼠仓鼠
重量 (kg)0.020.151.80.40.0810
体表面积 (m2)0.0070.0250.150.050.020.5
Km系数36128520
动物 A (mg/kg) = 动物 B (mg/kg) × 动物 B的Km系数
动物 A的Km系数

例如,依据体表面积折算法,将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量,需要将20 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到化合物用于大鼠的等效剂量为10 mg/kg。


储备液配制

以下数据基于产品分子量,对于特殊产品,请参照COA中的储备液配制条件和说明进行操作。

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
1 mM1.6266 mL8.133 mL16.266 mL
5 mM0.3253 mL1.6266 mL3.2532 mL
10 mM0.1627 mL0.8133 mL1.6266 mL