(Rac)-Indoximod

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(Rac)-Indoximod

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

26988-72-7

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
50mg	电议
100mg	电议
200mg	电议

产品名称

1-Methyl-DL-tryptophan
(Rac)-NLG-8189

产品介绍

(Rac)-Indoximod (1-Methyl-DL-tryptophan) 是吲哚胺-2,3-双加氧酶 (IDO) 抑制剂。(Rac)-Indoximod 和 IFN-γ 联用显著降低了表达 α-SMA 的人心肌成纤维细胞活性，并通过上调 IRF-1，Fas 和 FasL 基因诱导凋亡(apoptosis)。

生物活性

(Rac)-Indoximod (1-Methyl-DL-tryptophan) is anindoleamine 2,3-dioxygenase(IDO) inhibitor. Co-treatment withIFN-γand (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and inducesapoptosisthrough up-regulating the IRF-1,Fas, and FasL genes^[1].

IC₅₀& Target^[1]

IDO

体外研究
(In Vitro)

(Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death regardless of tryptophan depletion^[1].

Cell Viability Assay^[1]

Cell Line:	Human cardiac myofibroblasts (hCMs)
Concentration:	0.5 mM
Incubation Time:	3 days
Result:	Growth retardation by IFN-γ was partially reversed on day 2, but cell viability was further reduced on day 3.

分子量

218.25

性状

Solid

Formula

C₁₂H₁₄N₂O₂

CAS 号

26988-72-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

0.1 M NaOH : 10 mg/mL(45.82 mM;Need ultrasonic)

DMSO : 4.76 mg/mL(21.81 mM;ultrasonic and warming and adjust pH to 4 with HCl and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	4.5819 mL	22.9095 mL	45.8190 mL
5 mM	0.9164 mL	4.5819 mL	9.1638 mL
10 mM	0.4582 mL	2.2910 mL	4.5819 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。