Bictegravir sodium is a potent inhibitor ofHIV-1integrase, with anIC₅₀of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity^[1].

Bictegravir sodium potently inhibits HIV-1 replication in both MT-2 and MT-4 cells with EC₅₀s of 1.5 and 2.4 nM, respectively, and selectivity indices (50% cytotoxic concentration [CC₅₀]/EC₅₀) of ~6,800 in MT-2 cells and ~1,500 in MT-4 cells^[1].

471.36

Solid

C₂₁H₁₇F₃N₃NaO₅

1807988-02-8

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

DMSO : 16.67 mg/mL(35.37 mM;ultrasonic and warming and heat to 60℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。