Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities^[1].

Fucoidan is a biologically active polysaccharide found in great abundance in brown marine algae^[1].
Fucoidan extracted fromA. nodosumis a more potent inhibitor of α-glucosidase, with an IC₅₀ranging from 0.013 to 0.047 mg/mL, than the inhibition by Fucoidan extracted fromF. vesiculosus(IC₅₀=0.049 mg/mL). Fucoidan extracted fromF. vesiculosusdoes not inhibit α-amylase activity, while Fucoidan fromA. nodosumdecreases α-amylase activity by 7-100% at 5 mg/mL depending upon the algae harvest period. Fucoidan fromA. nodosuminhibits α-amylase with an IC₅₀of 0.12-4.64 mg/mL^[1].
Fucoidan is a fucose-rich sulfated polysaccharide typically found in the cell wall of marine algae but also recently isolated from terrestrial sources. Fucoidan exhibits an attractive therapeutic potential against a wide array of metabolic diseases associated with oxidative stress^[2].

Fucoidan (single injection of 25 mg/kg/body) does not inhibit tumor cell proliferation, while three-time injections of 10 mg/kg/body weight significantly reduces tumor growth and metastasis^[3].

Solid

9072-19-9

岩藻多糖；褐藻糖胶

Room temperature in continental US; may vary elsewhere.

H₂O : 20 mg/mL(ultrasonic and warming and heat to 60℃)

DMSO :< 1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble or slightly soluble)

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 33.33 mg/mL (Infinity mM); Clear solution; Need ultrasonic and warming and heat to 60℃