FBPase-IN-1

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FBPase-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

20362-54-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

FBPase-IN-1 是一种有效的FBPase(Fructose-1,6-bisphosphatase) 抑制剂，IC₅₀为 0.22 μM，可用于二型糖尿病研究。FBPase-IN-1 可降低血糖水平，改善糖耐量。FBPase-IN-1 修饰 C128 位点，调控 FBPase 的 N125-S124-S123 变构通路，影响FBPase的催化活性。

生物活性

FBPase-IN-1 is a potentFBPase(Fructose-1,6-bisphosphatase) inhibitor for Type 2 diabetes (T2D) study with anIC₅₀of 0.22 μM. FBPase-IN-1 can reduce blood glucose levels and ameliorate glucose tolerance. FBPase-IN-1 modifies the C128 site, regulates the N125-S124-S123 allosteric pathway ofFBPaseand affects the catalytic activity ofFBPase^[1].

IC₅₀& Target

IC₅₀: 0.22 μM (FBPase)^[1]

体外研究
(In Vitro)

FBPase-IN-1 (compund 3a) (1.5625-200 μM, 48 hours) shows a low cytotoxicity with anIC₅₀of 75.08 μM^[1].
FBPase-IN-1 (0-45 min) inhibits FBPase in a time-dependent manner, withIC₅₀decreasing from 0.28 to 0.09 μM, shows FBPase-IN-1 is an irreversible covalent inhibitor of FBPase^[1].

体内研究
(In Vivo)

FBPase-IN-1 (12 h-fasted ICR mouse, n = 6, male, 25 mg/kg, IP) shows good FBPase inhibitory activity (IC₅₀= 0.22 μM), satisfying glucose-lowering effectin vivo(54% reduction in blood glucose at 25 mg/kg)^[1].
FBPase-IN-1 (6 or 7 weeks, ICR mice, n = 6, male, 25 mg/kg, IP for 4 hours, once) reduces blood glucose levels by targeting FBPase and inhibiting the GNG process^[1].

Animal Model:	ICR mouse (12 h-fasted, n = 6, male)^[1]
Dosage:	25 mg/kg
Administration:	IP, once
Result:	Lowered glucose.

Animal Model:	ICR mice (6 or 7 weeks, n = 6, male)^[1]
Dosage:	25 mg/kg
Administration:	IP, for 4 h, once
Result:	Reduced blood glucose levels by targeting FBPase and inhibiting the GNG process.

分子量

232.37

Formula

C₆H₄N₂S₄

CAS 号

20362-54-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.