| CAS NO: | 226929-39-1 |
| 包装: | 5mg |
| 市场价: | 4000元 |
| 生物活性 | LB42708 is a potent, selective and orally activefarnesyltransferaseinhibitor. LB42708 inhibits farnesylation ofH-Ras,N-RasandK-Ras4BwithIC50s of 0.8 nM, 1.2 nM and 2.0 nM, respectively[1]. | |||||||||
| 体外研究 (In Vitro) | LB42708 induces cell death despite K-ras prenylation. Growth inhibition by LB42708 is accompanied by G1 and G2/M cell cycle arrests in H-ras and K-ras-transformed RIE cells, respectively. LB42708 induces the upregulation of p21(CIP1/WAF1) and RhoB above the basal level that leads to the cell cycle arrest and to distinct morphological alterations of ras-transformed rat intestinal epithelial (RIE) cells[2]. | |||||||||
| 分子量 | 555.47 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C30H27BrN4O2 | |||||||||
| CAS 号 | 226929-39-1 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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