ABT-100

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ABT-100

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

450839-40-4

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议

产品介绍

ABT-100 是一种有效的，高选择性和口服活性的farnesyltransferase抑制剂。ABT-100 抑制细胞增殖 (对于 EJ-1，DLD-1，MDA-MB-231，HCT-116，MiaPaCa-2，PC-3 和 DU-145 细胞的IC₅₀分别为 2.2 nM，3.8 nM，5.9 nM，6.9 nM，9.2 nM，70 nM 和 818 nM)，可增加细胞凋亡并减少血管生成。ABT-100 具有广谱抗肿瘤活性。

生物活性

ABT-100 is a potent, highly selective and orally activefarnesyltransferaseinhibitor. ABT-100 inhibits cell proliferation (IC₅₀s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increasesapoptosisand decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity^[1].

IC₅₀& Target

Farnesyltransferase^[1]

体外研究
(In Vitro)

ABT-100 (0.1-100 nM; 7 days; EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells) treatment shows dose-dependent growth inhibition of human cancer cell lines. Also inhibits colony formation at concentrations comparable with which ABT-100 inhibits anchorage-dependent growth^[1].

Cell Proliferation Assay^[1]

Cell Line:	EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells
Concentration:	0.1-100 nM
Incubation Time:	7 days
Result:	Demonstrated dose-dependent growth inhibition of human cancer cell lines.

体内研究
(In Vivo)

ABT-100 (6.25-12.5 mg/kg/day; subcutaneous injection; daily; for 21 days; C.B-17 scid male mice) treatment regresses EJ-1 tumors in mice^[1].

Animal Model:	C.B-17 scid male mice with EJ-1 cells^[1]
Dosage:	6.25 mg/kg/day, 12.5 mg/kg/day
Administration:	Subcutaneous injection; daily; for 21 days
Result:	Regressed EJ-1 tumors in C.B-17 scid male mice.

分子量

504.46

性状

Solid

Formula

C₂₇H₁₉F₃N₄O₃

CAS 号

450839-40-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 50 mg/mL(99.12 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.9823 mL	9.9116 mL	19.8232 mL
5 mM	0.3965 mL	1.9823 mL	3.9646 mL
10 mM	0.1982 mL	0.9912 mL	1.9823 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。