| CAS NO: | 2098724-83-3 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 生物活性 | Abelacimab (MAA868) is a fully humanIgG1monoclonal antibody that binds with high affinity to the catalytic structural domain ofFXIand locks it in the zymogen conformation, thereby preventing its activation by FXIIa orthrombin. Abelacimab can be used in thromboembolic disease studies[1][2]. |
| 体外研究 (In Vitro) | Abelacimab (MAA868) (0.0001-1 μM) 以浓度依赖的方式延长凝血时间并减少人血浆中的凝血酶数量[1]。 |
| 体内研究 (In Vivo) | Abelacimab (MAA868) (s.c., 3-30 mg/kg, on day 1, 85, 114) 在食蟹猴中表现出强烈和持续的抗凝血作用，显着延长 aPTT，且具有较好的安全性，未观察到显着的毒性发现或出血迹象[1]。 |
| CAS 号 | 2098724-83-3 |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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