您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Lonidamine
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Lonidamine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Lonidamine图片
CAS NO:50264-69-2
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议

产品介绍
Lonidamine (AF-1890) 是一种己糖激酶和线粒体丙酮酸载体抑制剂（Ki:2.5 μM）。
Cas No.50264-69-2
别名氯尼达明; AF-1890; Diclondazolic Acid; DICA
化学名1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid
Canonical SMILESC1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O
分子式C15H10Cl2N2O2
分子量321.16
溶解度≥ 11.1mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lonidamine (AF-1890), an antitumor agent, is a hexokinase, mitochondrial pyruvate carrier (Ki 2.5 μM in isolated rat liver mitochondria) and plasma membrane monocarboxylate transporters inhibitor, which also inhibits mitochondrial complex II[1][2].

References:
[1]. Guo L, et al. Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine. J Biol Chem. 2016 Jan 1;291(1):42-57.
[2]. Nancolas B, et al. The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. Biochem J. 2016 Apr 1;473(7):929-36.