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L-Leucyl-L-Leucine methyl ester(hydrochloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
L-Leucyl-L-Leucine methyl ester(hydrochloride)图片
CAS NO:6491-83-4
包装与价格：
包装价格(元)
100mg电议
250mg电议
1g电议

产品介绍
L-Leucyl-L-Leucinemethylester (LLOMe) hydrochloride 是由人类单核细胞或多形核白细胞产生的 L-亮氨酸甲酯的二肽缩合产物，可选择性地消除具有细胞毒性潜力的淋巴细胞。
Cas No.6491-83-4
别名LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride
化学名L-leucyl-L-leucine, methyl ester, monohydrochloride
Canonical SMILESCOC([C@@H](NC([C@@H](N)CC(C)C)=O)CC(C)C)=O.Cl
分子式C13H26N2O3•HCl
分子量294.8
溶解度30mg/mL in DMSO, 10mg/mL in DMF, 30mg/mL in Ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells. [1] [2] It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. [2] Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells. [2]

Reference:
[1]. Ohlin, M., Danielsson, L., Carlsson, R., et al. The effect of leucyl-leucine methyl ester on proliferation and Ig secretion of EBV-transformed human B lymphocytes. Immunology 66(4), 485-490 (1989).
[2]. Thiele, D.L., and Lipsky, P.E. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: Dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proceedings of the National Academy of Sciences of the United States of America 87(1), 83-87 (1990).