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Hypericin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Hypericin图片
CAS NO:548-04-9
包装:10mg
市场价:1620元

产品介绍
金丝桃素是在 Hyperlcurn perforatum L 中发现的一种天然物质。
Cas No.548-04-9
别名金丝桃素
Canonical SMILESCC1=CC(=C2C3=C1C4=C5C(=C(C=C4C)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O
分子式C30H16O8
分子量504.45
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml,Ethanol: slightly soluble
储存条件Store at 2-8℃,protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM. IC50: 7.5 uMIn vitro:The photosensitive of hypericin can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion. PDT with hypericin results in the activation of multiple pathways that can either promote or counteract the cell death program. It can effect cytotoxic to tumor cells by visible light.

References:
[1]. Agostinis P et al. Hypericin in cancer treatment: more light on the way.Int J Biochem Cell Biol. 2002 Mar;34(3):221-41.
[2]. Lenard J et al. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses usinghypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):158-62.
[3]. Hwang MS et al. Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin.Anticancer Res. 2001 Jul-Aug;21(4A):2649-55.