ML390 is a potentdihydroorotate dehydrogenase(DHODH)inhibitor. ML390 is an inducer of myeloid differentiation and causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) acute myeloid leukemia (AML) models^[1][2][3].

ML390 is active with an ED₅₀of ~2 μM in murine and human AML cell lines. In vitro, treatment of Lys-GFP-ER-HoxA9 cells with ML390 for 48 hr inhibits DHODH activity, leading to the dramatic (>500-fold) accumulation of the upstream metabolite DHO and the depletion of uridine and other downstream metabolites^[2].

406.40

Solid

C₂₁H₂₁F₃N₂O₃

2029049-79-2

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 27 mg/mL(66.44 mM)

*"≥" means soluble, but saturation unknown.

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