CAS NO: | 113857-87-7 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Talotrexin (PT523), an analog ofAminopterin(HY-14518), is a nonpolyglutamatable classicantifolate. Talotrexin is aRFC (reduced folate carrier)specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targetingDHFRto inhibit tumor growth[1][2]. | ||||||||
体外研究 (In Vitro) | Talotrexin 未显示出显著的 PCFT 或 FRα 抑制活性[1]。 | ||||||||
体内研究 (In Vivo) | Talotrexin (0-35 mg/kg,静脉注射,每周一次,持续 4 周) 单独或与Paclitaxel(HY-B0015, 7.5 mg/kg) 联合使用可抑制小鼠 A549 肿瘤的生长[2]。
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分子量 | 573.56 | ||||||||
Formula | C27H27N9O6 | ||||||||
CAS 号 | 113857-87-7 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |