Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of theparasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity withIC₅₀values of 460 nM and 2.0 nM, respectively. Atovaquone is anantimalarial agentand has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia^[1][2].

Atovaquone targets to the Q_o site of the Plasmodium cytochrome bc1 complex of the mitochondrial electron transport chain^[1].
Atovaquone is against the development in the mosquito from gamete production, through fertilization, zygote formation and finally, to the development of the mature ookinete, and demonstrates an IC₅₀ of 67 nM providing further evidence of the transmission blocking potential of this molecule^[1].

Atovaquone (oral administration; 100 mg/kg; once daily) is against survival rates of mice, mice treated orally died within 22 days after discontinuation of sulfadiazine,while the control group died at day 14^[2].

366.84

Solid

C₂₂H₁₉ClO₃

95233-18-4

阿托伐醌

Room temperature in continental US; may vary elsewhere.

DMSO : 8.33 mg/mL(22.71 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： 10% DMSO    40%PEG300   5%Tween-80   45% saline

  Solubility: 0.83 mg/mL (2.26 mM); Suspended solution; Need ultrasonic

  此方案可获得 0.83 mg/mL (2.26 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

  以 1 mL 工作液为例，取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

  将 0.9 g 氯化钠，完全溶解于 100 mL ddH2O 中，得到澄清透明的生理盐水溶液
• 2.

  请依序添加每种溶剂： 10% DMSO    90%corn oil

  Solubility: ≥ 0.83 mg/mL (2.26 mM); Clear solution

  此方案可获得 ≥ 0.83 mg/mL (2.26 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

  以 1 mL 工作液为例，取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。