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Tetraethylammonium chloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tetraethylammonium chloride图片
CAS NO:56-34-8
包装:500mg
市场价:450元

产品介绍
Tetraethylammonium chloride 是一种非选择性钾通道阻滞剂。
Cas No.56-34-8
别名四乙基氯化铵
化学名tetraethylammonium chloride
Canonical SMILESCC[N+](CC)(CC)CC.[Cl-]
分子式C8H20ClN
分子量165.2
溶解度≥ 16.5mg/mL in Ethanol
储存条件Store at 4°C, sealed storage, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tetraethylammonium chloride (TEAC) is a quaternary ammonium compound, which has been used as the source of tetraethylammonium ions in pharmacological and physiological studies.

In vitro: Tetraethylammonium (TEA) is a small ion that is thought to block open K channels by binding either to an internal or to an external site. For this reason, it has been used to probe the ion conduction pathway or pore of K channel mutants and a K channel chimera. TEA blocks K+ channels at two sites, which define the inner and outer mouths of the channel pores [1].

In vivo: Vasorelaxant effect of taurine can be diminished by TEA in rat isolated arteries [2]

Clinical trial: TEAC blocks both sympathetic and parasympathetic transmission at the ganglia. TEAC can relieve the pain of coronary artery disease. By the use of TEAC, the symptoms of Buerger's disease seem to be meliorated, at least temporarily. TEAC appears to be of little value in advanced arteriosclerotic diseases [3].

References:
[1] Taglialatela M, Vandongen AM, Drewe JA, Joho RH, Brown AM, Kirsch GE.  Patterns of internal and external tetraethylammonium block in four homologous K+ channels. Mol Pharmacol. 1991 Aug;40(2):299-307.
[2] Niu LG, Zhang MS, Liu Y, Xue WX, Liu DB, Zhang J, Liang YQ.  Vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries. Eur J Pharmacol. 2008 Feb 2;580(1-2):169-74. Epub 2007 Oct 25.
[3] SHEA PA, DUNKLEE PE, et al.  Preliminary clinical investigation of tetraethylammonium chloride with particular reference to disorders of the circulatory system. Calif Med. 1948 Sep;69(3):193-6.