| CAS NO: | 217171-01-2 |
| 包装: | 10mg |
| 市场价: | 2132元 |
| Cas No. | 217171-01-2 |
| 别名 | N-[[4-叔丁基苯基]甲基]-N-甲基-L-亮氨酰-N-叔丁基-O-苄基-L-酪氨酰胺 |
| 化学名 | (S)-N-((S)-3-(4-(benzyloxy)phenyl)-1-(tert-butylamino)-1-oxopropan-2-yl)-2-((4-(tert-butyl)benzyl)(methyl)amino)-4-methylpentanamide |
| Canonical SMILES | O=C([C@H](CC(C)C)N(C)CC(C=C1)=CC=C1C(C)(C)C)N[C@H](C(NC(C)(C)C)=O)CC(C=C2)=CC=C2OCC3=CC=CC=C3 |
| 分子式 | C38H53N3O3 |
| 分子量 | 599.85 |
| 溶解度 | DMSO: 100 mM,Ethanol: 100 mM |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays. PD173212 (PD 173212, 300 nM) potently blocks recombinant B-class (N-type) calcium channel currents 78±7.8%, with an IC50 of 74 nM, by whole-cell voltage-clamp techniques. PD 173212 possesses selectivity for non L-type Ca2+ channels versus neuronal Na+, K+, and L-type Ca2+ channels[1]. PD173212 (30 mg/kg, i.v.) shows moderate efficacy in preventing tonic seizures in the audiogenic seizure model[1]. References: |
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