CAS NO: | 147098-20-2 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
生物活性 | Rosuvastatin Calcium is a competitiveHMG-CoA reductase (HMGCR)inhibitor, with anIC50of 11 nM. Rosuvastatin Calcium potently blockshERGcurrent with anIC50of 195 nM[2]. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction ofheat shock protein70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL)cholesterol, triglycerides, and C-reactive protein levels[1][2][3]. | ||||||||||||||||
IC50& Target | IC50: 11 nM (HMG-CoA), 195 nM (hERG)[1][2] | ||||||||||||||||
体内研究 (In Vivo) | Rosuvastatin Calcium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 500.57 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C22H27Ca0.5FN3O6S | ||||||||||||||||
CAS 号 | 147098-20-2 | ||||||||||||||||
中文名称 | 瑞舒伐他汀钙;罗苏伐他汀钙;罗素他汀钙;罗伐他汀钙 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 25 mg/mL(49.94 mM;Need ultrasonic) H2O : 1 mg/mL(2.00 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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