Avatrombopag maleate

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

677007-74-8

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

AKR-501 maleate
E5501 maleate
YM477 maleate

产品介绍

Avatrombopag maleate (AKR-501) 是一种口服活性的非肽血小板生成素受体 (TPO receptor) 激动剂 (EC₅₀=3.3 nM)。Avatrombopag maleate 可模拟 TPO 的生物活性。Avatrombopag maleate 通过激活细胞内信号传导系统来增加血小板的产生，并促进造血前体细胞产生血小板和巨核细胞。Avatrombopag maleate 是细胞色素 P450 (CYP) 2C9 和 CYP3A 的底物。

生物活性

Avatrombopag maleate (AKR-501) is an orally active, nonpeptidethrombopoietin (TPO) receptoragonist (EC₅₀=3.3 nM). Avatrombopag maleate mimics the biological activities of TPO. Avatrombopag maleate increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag maleate is a substrate ofcytochrome P450(CYP) 2C9 and CYP3A^[1]^[2]^[3].

Clinical Trial

分子量

765.73

Formula

C₃₃H₃₈Cl₂N₆O₇S₂

CAS 号

677007-74-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.