C-176

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C-176

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

314054-00-7

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

C-176 是干扰素基因刺激受体(STING)的强效共价抑制剂。

生物活性

C-176 is a strong and covalent mouseSTINGinhibitor^[1].

IC₅₀& Target

STING^[1].

体外研究
(In Vitro)

C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6^[1].

体内研究
(In Vivo)

C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity^[1].
C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1^–/–mice^[1].
C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1^–/–mice^[1].

Animal Model:	WT type mice.
Dosage:	750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL).
Administration:	Intraperitoneally, once.
Result:	Significantly reduced Serum levels of type I IFNs and IL-6.

分子量

358.09

性状

Solid

Formula

C₁₁H₇IN₂O₄

CAS 号

314054-00-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 62.5 mg/mL(174.54 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.7926 mL	13.9630 mL	27.9259 mL
5 mM	0.5585 mL	2.7926 mL	5.5852 mL
10 mM	0.2793 mL	1.3963 mL	2.7926 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。