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trans-Ned 19
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
trans-Ned 19图片
CAS NO:1354235-96-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
trans-Ned 19 是一种 NAADP 拮抗剂和 TPC 阻滞剂,可抑制人脐静脉内皮细胞 (HUVEC) 中的钙信号和响应低组胺浓度的大鼠主动脉松弛。
Cas No.1354235-96-3
化学名(1R,3S)-1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Canonical SMILESCOC1=C(CN2CCN(C3=CC=CC=C3F)CC2)C=C([C@]4([H])C5=C(C6=CC=CC=C6N5)C[C@@](N4)([H])C(O)=O)C=C1
分子式C30H31FN4O3
分子量514.59
溶解度DMF: 10 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

trans-Ned 19, a NAADP antagonist and TPC blocker, suppresses the calcium signal in human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations[1].

References:
[1]. Zharkich IL, et al. Suppression of Histamine-Induced Relaxation of Rat Aorta and Calcium Signaling in Endothelial Cells by Two-Pore Channel Blocker trans-NED19 and Hydrogen Peroxide. Izv Akad Nauk Ser Biol. 2016 Jul;(4):430-438.